Gene 2 Structure Consulting

Gene 2 Structure ConsultingGene 2 Structure ConsultingGene 2 Structure Consulting

Gene 2 Structure Consulting

Gene 2 Structure ConsultingGene 2 Structure ConsultingGene 2 Structure Consulting

structural biology specialists

structural biology specialistsstructural biology specialistsstructural biology specialists

 Gene 2 Structure is a San Diego – based consulting firm specializing in both in-house and outsourced gene-structure projects

structural biology specialists

structural biology specialistsstructural biology specialistsstructural biology specialists

 Gene 2 Structure is a San Diego – based consulting firm specializing in both in-house and outsourced gene-structure projects

About

Gene 2 Structure is a San Diego based, private structural biology consulting company focused on efficiently managing in-house and outsourced gene-structure projects. 


Our structural team has over 50 years combined experience in structure-based drug design encompassing Oncology, Immunology, GI/Metabolic, Neuroscience, Infectious and Rare disease indications. 


With decades of expertise in a variety of high-value target classes and significant contributions to dozens of small molecule and Biologic development candidates, we are an ideal partner to help advance your programs to the clinic. 

Services

Capabilities

Drawing on extensive drug discovery expertise, we design comprehensive gene-to-structure pipelines that encompass clone selection, protein expression, crystallization/grid freezing, X-ray diffraction or cryo-EM data acquisition, and high-resolution structure refinement—delivering robust and reproducible results.  

Value Added

We provide end-to-end management of both in-house and outsourced gene-to-structure programs, serving as the central point of contact between project teams and CRO partners. Our team ensures seamless coordination, expert troubleshooting at every stage, and hands-on refinement of structural solutions to consistently deliver high-quality results. 

Deliverables

We specialize in generating, solving, and refining X-ray crystallography and cryo-EM data, with a clear focus on communicating key structural insights that address project team objectives. By providing hands-on structure refinement and analysis, we minimize external exposure of experimental conditions and protect critical IP. Our fractional FTE model provides efficient, flexible, and cost-effective access to specialized expertise exactly when you need it.

Growth

Designed and built advanced in-house structural biology platforms for companies at both startup and large scale. 

The Team

Douglas Dougan

Chief Executive Officer/Founder

Robert Skene

Chief Scientific Officer/Founder

Derek Cole

Scientific Advisory Board

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